However, the presence of these proteins in the tumor was doubled in CAR tumors (laminin, 52 ± 5.9% and 23.3 ± 10.3% and collagen IV, 64.1 ± 11.7% and 36.5 ± 14.4%, in total CAR and MEL tumors, respectively), which reflects the ECM network that constituted the ECM-poor regions of CAR tumours but is absent in MEL tumors. This evidence concerns the gene LAMB2 and neoplasm.