Figure 8 suggests that lower pleomorphism corresponds to a better HR, where higher pleomorphism is associated with a higher tumor grade and worse prognosis. These observations are consistent with key diagnostic points in GBM, including cytological criteria of astrocytoma (e.g., GFAP, spindle-shape nuclei) and anaplasia (e.g., hypercellularity, pleomorphism, nuclear hyperchromasia) [23]. This evidence concerns the gene GFAP and astrocytoma (excluding glioblastoma).