Further investigations on the mode of action of PEITC revealed that PEITC targets the key signaling pathways of ovarian cancer because PEITC inhibited TGF-dependent activation of EGFR-Akt, and there was significant inhibition of Rictor, Raptor, mTORC1, and mTORC2 thereof [113]. This evidence concerns the gene AKT1 and ovarian cancer.