Furthermore, PEITC-mediated apoptosis induction was validated by increased activation of caspase-3, caspase-8, and caspase-9, and enhanced expression of Bax and c- PARP, while a significant reduction was noted in the expression of Bcl-2 in PEITC-exposed ovarian cancer cells [87]. The gene discussed is CASP3; the disease is ovarian cancer.