Interestingly, BITC inhibited Bcl-2 expression and up-regulated the expression of caspase-3, caspase-8, c-PARP, and Bax, seemingly via activation of JNK1/2/p38 and inhibition of ERK1/2 and Akt signaling in ovarian cancer cells [150]. The gene discussed is MAPK8; the disease is ovarian carcinoma.