Moreover, combinatorial treatment of PEITC and paclitaxel inhibited breast cancer cells synergistically, induced apoptosis through enhanced Bcl-2 inhibition, PARP cleavage, and Bax overexpression, and also triggered G2/M cell cycle arrest by down-regulating expression of cyclin B1 and CDK1 in MCF-7 and MDA-MB-231 cell lines [184,186]. This evidence concerns the gene BAX and breast carcinoma.