MAPK8 and ovarian cancer: Further investigations on the molecular mechanism of PEITC revealed that apoptosis induction in ovarian cancer cells occurred seemingly through increased phosphorylation of JNK1/2 and p38 and reduced phosphorylation of ERK1/2, Akt, and c-Myc, indicating PEITC targets JNK/p38 and ERK/Akt signaling pathways [87].