Another study showed that co-administration of SFN and cisplatin considerably attenuated TNBC cell proliferation (MDA-MB-231 and MDA-MB-468) by inducing apoptosis and S phase cell cycle arrest; synergistically reduced TNBC cell migration and invasion by decreasing MMP2 and MMP9 expression; reversed epithelial–mesenchymal transition (EMT) process by suppressing sirtuins (SIRTs); and decreased cancer cell stemness by down-regulating N-cadherin, vimentin, Slug, and Snail; and altered chromatin modifications of E-cadherin promoter [173]. This evidence concerns the gene SNAI2 and cancer.