Additionally, SFN and tamoxifen co-treatment also decreased ALDH activity and MFE in breast cancer cell lines (MCF-7, T47D, and ZR-75-1) and primary breast cancer cells while tamoxifen either alone or in combination with SFN increased bCSC activity measured by ALDH activity and MFE, but SFN alone was effective in reducing ALDH activity and MFE in patient-derived xenografted animals [162]. Here, LDHA is linked to breast cancer.