CASP3 and breast carcinoma: Furthermore, another interesting study demonstrated that PEITC-induced apoptosis in breast cancer cells was independent of the p53 up-regulated modulator of apoptosis (PUMA), but the apoptosis induction occurred in response to the B-cell lymphoma 2 interacting mediator of cell death (Bim), Bax, Bak, and caspase-3 activation [104].