ERBB2 and cancer: PEITC was reported to enhance the anticancer effects of doxorubicin at lower doses in HER2-positive cancer cell lines (MDA-MB-231 and MDA-MB-231 high HER2), and upon exploring the molecular mechanism, the PEITC and doxorubicin combination was found to down-regulate HER2, EGFR, and phosphorylated STAT3 while up-regulating c-caspase-3 and PARP [185].