TNF and colorectal cancer: Furthermore, data from a multicenter US large-scale database study revealed a significant reduction in the risk of colorectal cancer among patients receiving anti-TNF agents in both CD (OR 0.69; 95% CI, 0.66–0.73) and UC (OR 0.78; 95% CI, 0.73–0.83), as well as in combined treatment (anti-TNFα and immunomodulators) in CD (OR 0.73; 95% CI, 0.63–0.84) and UC (OR 0.83; 95% CI, 0.70–0.99) [65].