In renal cell carcinoma cells, PPARγ could bind to the PPRE promoter on the ACLY regulatory site to regulate ACLY transcriptional levels, and Von Hippel–Lindau (VHL) ubiquitinated PPARγ, leading to ACLY downregulation and a reduction in intracellular lipid accumulation in human renal carcinoma tissues [67]. Here, ACLY is linked to hereditary clear cell renal cell carcinoma.