PKM2 is overexpressed in non-small-cell lung cancer [48], melanoma [49], cervical cancer [50], etc. It has been reported that the ubiquitination of PKM2 occurs through its Lys48 and Lys63 ubiquitin sites, and that USP20 could stabilize the expression of PKM2 through its deubiquitination [51]. The gene discussed is PKM; the disease is melanoma.