Among them, USP28 binds to Myc through an interaction with nucleoplasmic FBW7α, which is essential in breast and colon tumor cell proliferation [139,140], and USP36 binds to nucleolar Fbw7γ and controls the nucleolar degradation pathway of c-Myc in lung and breast cancer cells [141,142]. The gene discussed is MYC; the disease is breast carcinoma.