Abnormally high levels of ACLY have been observed in several tumor tissues, and ACL represents a negative prognostic factor for several types of cancer, including non-small-cell lung cancer, CRC, renal cancer, ovarian cancer, breast cancer, bladder cancer, HCC, and glioblastoma, reflecting the increased activity of this lipase in cancer [65,66,67,68,69,70,71,72,73]. This evidence concerns the gene ACLY and neoplasm.