Several independent investigators have observed that there is dual involvement of the COX and LOX cascades in the development of multiple forms of cancer [16,22,23], and reciprocally, compounds such as curcumin and licofelone with activity against both inflammatory pathways have shown significant anti-cancer effects in cell lines and animal models of breast cancer, colon cancer, prostate cancer, and lung cancer [24,25,26,27]. The gene discussed is LOX; the disease is breast cancer.