Specifically, selective tissue-specific inhibition of the chief rate-limiting enzymes of the prostaglandin and leukotriene cascades encoded by COX1, COX2, ALOX5, ALOX5AP as well as the novel NAT gene, RP11-C672.2, may be effective in turning off multiple downstream tumor-promoting response genes of the model. This evidence concerns the gene PTGS1 and neoplasm.