In addition, it has been reported that UA induces endoplasmic reticulum (ER) stress and autophagy in MCF-7 human breast cancer cells, and autophagy-dependent endoplasmic reticulum stress protects cells from UA-induced apoptosis through EIF2AK3-mediated MCL1 upregulation. The gene discussed is EIF2AK3; the disease is breast carcinoma.