PTGES and gastrointestinal hamartoma: For example, mPGES-1 is overexpressed in gastrointestinal-hamartoma-induced mice [65], increases the number of aberrant crypt foci at an early stage and increases tumor size in mice colorectal cancer [66], and promotes intestinal tumorigenesis in LPS-induced transgenic mice [67]; meanwhile, mPGES-1 deletion suppresses intestinal tumorigenesis in Apc(Min/+) mice [68].