AKT1 and neoplasm: In vitro and in vivo studies demonstrate that PGE2 may induce epigenetic modifications that contribute to the growth and metastasis formation of breast and gastric cancer [22,23], promote miRNA modifications that contribute to modulate cancer cell growth and migration and tumor angiogenesis [24,25,26,27], and increases cancer cell growth, migration, and resistance to apoptosis through the modulation of several molecular pathways, such as JAK/STAT [28], PI3K/AKT [29], and RAS/Raf/MAPK signaling [30].