CD274 and neoplasm: A previous study by Horn and coworkers in 4T1 tumor-bearing mice showed that the addition of SX682 to bintrafusp alfa (M7824; bifunctional fusion protein composed of the extracellular domain of the human TGF-β receptor II and combined with anti-PD-L1 moiety) synergistically delayed tumor growth and improved the response to therapy in the 4T1 model, although no tumor eradications were observed [43].