Furthermore, ADAMTS12 (which has shown both pro- and anti-tumor roles and associated with immune cells [92]), neuropilin 2 and interleukin-7 (both of which act on immune cells and have shown great potential in cancer immunotherapy [93,94]) were only detected in our 10 K EVs and 100 K EVs, but not in any of our 18 K EVs, suggesting the presence of immune-associated proteins localized to the cargo of large (10 K) and small (100 K) EVs. Here, ADAMTS12 is linked to cancer.