This is consistent with the results from Javadi et al. (2021), who conducted a proteomics study of EV subpopulations derived from pleural mesothelioma pleural effusion samples [121] and found enrichment of cell surface tetraspanins CD9 in their large EV pellet (isolated at 10,000× g for 10 min and referred to as microvesicles), and enrichment of CD81 in their small EV pellet (isolated 100,000× g for 90 min and referred to as exosomes). Here, CD81 is linked to pleural mesothelioma.