The mitochondrial enzymes succinate dehydrogenase (SDHA), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH1) were detected in all our EV pellets (10 K, 18 K, and 100 K) derived from all our mesothelioma cell lines but were absent in all EV pellets derived from our control cell line, MeT-5A. Here, FH is linked to mesothelioma.