Among these, pleural mesothelioma-associated proteins include the programmed cell death 1 ligand 2 (PD-L2), which we found to be significantly overexpressed in only the 10 K EVs of VMC23 and MM05; bridging Integrator 1 (Bin1), which we have previously identified as a tumor suppressor and prognostic marker of pleural mesothelioma [89], was significantly under expressed in only the 18 K EVs of all pleural mesothelioma cell lines. The gene discussed is BIN1; the disease is pleural mesothelioma.