NOTCH3 and cancer: In the 100 K EVs, among the unique cancer-associated proteins, we found notch receptor 3 (NOTCH3), which plays a key role in the function and survival of vascular smooth muscle cells [85]; serine/threonine-protein kinase 10 (STK10), which functions as a tumor suppressor [86]; janus kinase 2 (JAK2), which plays a key role in cytokine and growth factor signaling [87]; and fanconi anemia group J protein (FANCJ), which plays an important role in cell cycle checkpoint control [88].