CTLA4 and neoplasm: While CD8+ T cells in the TCyEM group exerted a more robust cytotoxic anti-tumor phenotype, CD8+ T cells in the TCM group manifested a highly exhausted phenotype featuring the relatively higher expression of several exhaustion markers as previously described [80], including PDCD1, CTLA4, LAG3, and TIGIT, which is in agreement with the advanced stage of the disease identified in this group of patients.