While CD8+ T cells in the TCyEM group exerted a more robust cytotoxic anti-tumor phenotype, CD8+ T cells in the TCM group manifested a highly exhausted phenotype featuring the relatively higher expression of several exhaustion markers as previously described [80], including PDCD1, CTLA4, LAG3, and TIGIT, which is in agreement with the advanced stage of the disease identified in this group of patients. This evidence concerns the gene LAG3 and neoplasm.