CXCR2 and neoplasm: Furthermore, a study by Lim, Kim [93] and colleagues demonstrated that NK cells isolated from PDAC patient tumours had reduced expression of C-X-C motif chemokine receptor 2 (CXCR-2) when compared to healthy donor NKs, which is suggested to be responsible for the low numbers of NK cells seen within the PDAC TME [93].