IL6 and neoplasm: Signalling through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is initiated upon binding of cytokines such as interleukin (IL)-1 and IL-6 to their receptor, and is reported to enhance PDAC fibrosis, and ECM remodelling for increased stiffness of PDAC tumours [26,27,28].