EPAS1 and familial pancreatic carcinoma: While much is still to be uncovered about the VM potential of PDAC cells, Yang, Zhu [73] demonstrated that hypoxia-inducible factor 2 alpha (HIF-2α) promotes VM formation in vitro and in vivo through twist family basic helix-loop-helix (bHLH) transcription 1 (Twist1) binding to vascular endothelial-cadherin (VE-cadherin) in pancreatic cancer cells.