As an example, in xenografted pancreatic tumours, the exogenous delivery of a nanocarrier loaded with a plasmid DNA encoding soluble VEGF-1 (or soluble fms-like tyrosine kinase-1), a potent antiangiogenic protein, captured VEGF, exerting an antiangiogenic effect [78,79]. This evidence concerns the gene FLT1 and pancreatic neoplasm.