Decrease in DNAM-1 limits NK cytotoxicity and blocks IFNγ production, while the overexpression of DNAM-1 ligand in tumor cells causes a decrease in NKG2D ligands, indicating that NK cell-induced killing is initiated by DNAM-1 or NKG2D signaling pathway [74,117,119]. The gene discussed is KLRK1; the disease is neoplasm.