More recent studies have reported that replacement of “humanized” anti-CD16 single-domain camelid antibody from the anti-CD16 scFv enabled the use of wild-type IL15 instant of modified IL15 to build up cam16-wtIL15–33 TriKE, which exhibited more robust IL15 signaling and NK cell activation leading effective elimination of cancer by NK cells [243]. This evidence concerns the gene IL15 and cancer.