Furthermore, bispecific and trispecific multifunctional antibodies with Fc recognizing NK cell CD16a and one or more Fc regions for tumor antigens that preserve ADCC potential and physically tie NK cells to malignant cells through bispecific killer engagers (BiKEs) or trispecific killer engagers (TriKEs), therefore ensuing specificity and direct interaction between immune cells and tumors while low systemic toxicity [235,236] (Figure 4). This evidence concerns the gene FCGR3A and neoplasm.