CTNNB1 and metabolic dysfunction-associated steatotic liver disease: Immune exclusion correlated with CTNNB1 mutations in patients with NAFLD-HCC Specifically, CTNNB1 mutations lead to immune exclusion via the upregulation of TNFRSF19, which subsequently represses senescence-associated secretory phenotype (SASP)-like cytokines (including IL6 and CXCL8).