Several CAR-T agents (including anti-CD19 CAR-T (lisocabtagene), anti-CD20 CAR-T (C-CAR066), anti-CD19/CD20 CAR-T, and anti-CD20/CD22 CAR-T) are being tested as treatments for rituximab-resistant CLL in combination with other chemotherapeutics [6]. Here, CD22 is linked to B-cell chronic lymphocytic leukemia.