Another interesting protein is the formin-like 1 (FMNL1) protein, which is overexpressed in NSCLC and was detected in bone metastasis; in FMNL1-knockdown A549 and PC9 cells and in mice, the metastatic, migratory and invasive properties of cells are reduced via TGF-β/SMAD-mediated EMT inhibition [48]. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.