TGFB1 and cancer: The TGF-β superfamily, evolutionarily conserved [11], includes approximately 40 structurally and functionally related members, which are involved in different cellular events, including morphogenesis, embryonic development, inflammation and cancer [6], and exerts its functions through a set of receptors, such as the TGF-β type I (TGFβRI) and type II (TGFβRII) receptors [19].