In addition to regulation by non-coding RNAs, TGF-β can exert its influence on EMT by other effectors; G-protein regulator signaling 6, a tumor suppressor protein that negatively regulates TGF-β-induced EMT in NSCLC, and its low expression was associated with poor survival, which suggests that it is a possible LC prognostic marker [37]. This evidence concerns the gene TGFB1 and laryngotracheoesophageal cleft.