In addition, the overexpression of AlkB homolog 5 (ALKBH5), an RNA N6-methyladenosine (m6A) demethylase, suppresses TGF-β-induced EMT and invasiveness of NSCLC cells, reducing the mRNA stability of TGFβR2 and SMAD3, but increasing the mRNA stability of SMAD6 [56]. Here, SMAD3 is linked to non-small cell lung carcinoma.