TGFB1 and non-small cell lung carcinoma: Moreover, it has been shown, by transplanting cell tumors into nude mice, that the lysine-specific histone demethylase 1 (LSD1) demethylates the SEPT6 promoter, thus positively regulating Septin 6 (SEPT6), which, through the TGF-β/Smad pathway, accelerates metastasis in NSCLC [62].