It is well known that some of these natural derivates exhibit an antagonizing effect against TGF-β activities in lung cancer, as is the case of piperine, an amide derived from the Piper spices, which inhibits the TGF-β1 induced EMT, ERK 1/2 and SMAD 2 phosphorylation in A549 cells [74]. The gene discussed is TGFB1; the disease is lung cancer.