Interestingly, molecules inhibiting the metastatic effect mediated by TGF-β were discovered; among these crizotinib, a tyrosine kinase inhibitor, blocks TGF-β signaling by abrogating Smad pathway in an ALK/MET/RON/ROS1-independent manner in NSCLC cells [65], thereby inhibiting migration, invasion and metastasis. The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.