CD4 and immune system disorder: Regarding disease-free survival, low T-cell CD4+ counts should alert pediatricians of the need to verify adherence to cART for the rest of patients’ lives after the diagnosis of lymphoma and to adopt supportive measures for possible concurrent immunodeficiency states, such as prolonged neutropenia (use of G-CSF, preemptive diagnosis of fungal infections, and prophylaxis for opportunistic infections) and low immunoglobulin counts (immunoglobulin replacement if applicable).