In colorectal carcinoma, tumors with simultaneous presence of a high TMB and MSI/dMMR correspond to the CMS1 subtype [156], which is characterized by hypermutation, hypermethylation, enrichment in BRAF V600E mutations, as well as a strong infiltration of the tumor microenvironment with immune cells [88,157,158]. The gene discussed is BRAF; the disease is neoplasm.