The genetic landscape is characterized by mutations in genes typically altered in FL, such as BCL2, KMT2D, CREBBP, EZH2, and TNFRSF14, as well as in genes typically mutated in Burkitt lymphomas (BLs), such as MYC, CCND3, FOXO1, and others [46] and, therefore, differs from DLBCL, NOS as well as from FL and BL. The gene discussed is EZH2; the disease is Burkitt lymphoma.