Moreover, 5–10% of GCB-DLBCL harbor dual rearrangements of MYC and BCL2 genes (with or without additional BCL6 translocations) [14,15] which, however, although morphologically indistinguishable from bona fide DLBCL, NOS, are separately classified as diffuse large B-cell lymphoma with MYC and BCL2 rearrangements (see below). This evidence concerns the gene MYC and diffuse large B-cell lymphoma.