Aggressive lymphomas with simultaneous rearrangements of MYC and BCL6 are considered a genetic subtype of DLBCL, NOS, and in around 30% of these cases, MYC is directly translocated to BCL6 forming a BCL6::MYC fusion as a result of the t(3;8)(q27;q24) [21]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.