Plasma cell myeloma/multiple myeloma (PCM/MM) with plasmablastic features are a relevant differential diagnosis of PBL because the morphology and the immunophenotype of PBL and PCM/MM are nearly identical and because both MYC rearrangements and EBV-association have been noted in plasmablastic PCM/MN; therefore, the clinical presentation is often crucial in rendering the correct diagnosis [139,140,141]. This evidence concerns the gene MYC and plasma cell myeloma.