In contrast to the rare precursor cell (lymphoblastic) neoplasms with MYC or dual MYC and BCL2 translocations, the MYC translocation in DLBCL/HGBL-MYC/BCL2 obviously arises on the constraints of a pre-existing BCL2 translocation and, according to the structure of the IG breakpoints, takes place in the GC. Here, BCL2 is linked to high grade B-cell lymphoma.