Although a limitation of this study is that our in vivo findings were in immunocompromised mice, preventing us from determining the influence of Kaiso on immune cell populations such as T-cells, we were able to examine the Kaiso/CD47/SIRPA/THBS1 relationship for breast cancer patients in two independent datasets, BRCA cell lines, and TCGA [63,64,65,66,81,88]. Here, SIRPA is linked to breast cancer.