EZH2 and thymic large cell neuroendocrine carcinoma: EZH2 immunoreactivity has also been reported in thymic neuroendocrine neoplasms, with one study showing >25% EZH2 staining in 83% (5/6) of thymic large cell neuroendocrine carcinomas and 0/5 carcinoid tumors [20], and a separate study reporting >1% EZH2 staining in 37% (10/27) of thymic carcinoid tumors [21].