The findings of Figure 4B1 Indicate that the S727-STAT3 site was phosphorylated already at 10 min after tumor cell stimulation, and its phosphorylation decayed at the late points of 24 and 96 h (Figure 4B1 and Figure S2); in parallel, the Y705-STAT3 site was phosphorylated at relatively slow kinetics, noted from 24 h post TME Stimulation and increasing at 96 h of TME Stimulation (Figure 4B2 and Figure S2). This evidence concerns the gene STAT3 and neoplasm.