This was corroborated by the TNMplot.com public dataset [25] analyses, which demonstrated that SFRP1 expression was lower in tumoral breast tissue (fold change (FC) = 0.20) compared to normal breast tissue, and lower in metastatic (FC = 0.77) compared to breast tumors (Kruskal-Wallis p-value < 0.0001; Figure 1A). Here, SFRP1 is linked to breast neoplasm.