SFRP1 and ductal breast carcinoma in situ: However, we observed that SFRP1 overexpression in MCF10DCIS increased ESR1 expression, and then increased cell migration abilities in E2 conditions, while it decreased this expression in EtOH condition, suggesting that the role of SFRP1 in ERα-negative ductal carcinoma in situ could be E2-dependent.