The most relevant result of our present study has been to set an optimized basal Tg cutoff at 0.39 ng/mL able to provide high diagnostic performance and retain an independent prognostic role, regardless of other routinely considered risk factors such as age, gender, histotype, histological variant, tumor size, malignant nodule topography and risk classification according to 2015 ATA. Here, TG is linked to neoplasm.