Finally, in univariate and multivariate logistic regression analysis, the basal Tg cut-off emerged as the only independent predictor of positive 123I-Dx-WBS-SPECT/CT results regardless of age, gender, histotype, histological variant, tumor size, malignant nodule topography or risk classification, according to 2015 ATA (Table 7). The gene discussed is TG; the disease is neoplasm.