MYC and neoplasm: Moreover, some emerging evidence has demonstrated that perturbing STAT3 function in MB inhibits cell and tumor growth; however, a detailed mechanistic study using a systematic approach, considering the inducible genetic KD and simultaneous effect of pharmacologic inhibition of STAT3 on MYC gene regulation, orthotopic MB tumor growth and chemosensitivity, has not been performed in MB [14,48,49,50].