The cBioPortal database on the advanced PCa-associated bone metastasis cases [206,243] revealed significantly higher levels of PAK1 mRNA levels in patients with high Gleason scores compared to low Gleason score tissues, and in patients with PCa spread to lymph nodes and surrounding tissues, suggesting a linkage between PAK1 expression with PCa spread. This evidence concerns the gene PAK1 and posterior cortical atrophy.