First, we analyzed the differences in the expression of NRPs in PAAD tumor samples and normal pancreas samples, and the results showed that both, NRP1 and NRP2, were significantly more expressed in PAAD tumor samples (p < 0.001, Figure 1A), and 17 other cancer types had similar results (Supplementary Figure S1A). This evidence concerns the gene NRP1 and pancreatic adenocarcinoma.