CASP3 and cervical carcinoma: Additionally, Jiang et al. examined the effects of the proteasome inhibitor bortezomib and suberoylanilide hydroxamic acid in human cervical cancer cells and noted a significant increase in both caspase-3 stimulation and Bcl-2-associated X (Bax)/Bcl-2 expression, decreased nuclear transportation of nuclear factor-κB (NF-κB), as well as downregulation of Akt expression and phosphorylation [66].