HDAC1 and neoplasm: Raina et al. applied chrysin to HeLa cells and reported dose-dependent epigenetic alterations in terms of HDAC1/2/3/4/11 expression [131], whereas Mazzio et al. conducted high-throughput screening of non-fermented nutraceuticals and food-based polyphenolics and showed that, in HeLa cells, 13 plant-based HDACIs resemble trichostatin A by promoting the expression of microRNAs responsible for tumor suppression [132].