AKT1 and cervical carcinoma: Rocha et al. proposed methylation status modulation of lysine residues 4, 9, and 27, in histone H3, following treatment with valproic acid in HeLa cells [80], while Zhao et al. investigated the effects of valproic acid on the angiogenesis of cervical cancer and revealed inhibition of PI3K/Akt and ERK1/2 pathways to suppress HIF-1a and VEGF [81].