Accordingly, Zhang et al. synthesized palladium nanoparticles which, in combination with trichostatin A, had a synergistic effect on cytotoxicity, oxidative stress, mitochondrial membrane potential, caspase-3/9 activity, as well as the expression of pro- and anti-apoptotic genes in cervical cancer cells [53]. This evidence concerns the gene CASP3 and cervical carcinoma.