Lin et al. described a synergistic effect of trichostatin A or vorinostat and bortezomib in both inducing caspase-mediated apoptosis in HeLa cells and significantly more effectively retarding tumor growth in vivo [50], while Chakraborty et al. preincubated HeLa cells with trichostatin A prior to scaffold/matrix attachment region-binding protein 1 (SMAR1) upregulation by curcumin and revealed that HDAC1 activity weakened SMAR1-mediated E6 transcriptional repression [51]. Here, HDAC1 is linked to neoplasm.