CD163 and cancer: However, higher densities were seen in the hotspots in the patients who died of their cancer or of other causes within five years for CD68+ macrophages (mean ranks: 24.3 vs. 12.7, U = 5, adjusted p = 0.035 and mean ranks: 23.8 vs. 13.0, U = 11, adjusted p = 0.035, respectively) or within 10 years for CD163+ macrophages (mean ranks: 18.7 vs. 9.9, U = 16, adjusted p = 0.012 and mean ranks: 20.6 vs. 10.6, U = 27, adjusted p = 0.006, respectively) (Figure 7b).