NFKB1 and malignant colon neoplasm: For example, hepatocellular carcinoma upregulates the EZH2-associated lncRNA (HEIH), binds to miR-939, and then sponges the downstream function of miR-399, thus blocking the interaction between miR-939 and nuclear factor-kB (NF-κB) and improving NF-κB-mediated Bcl-xL expression for anti-apoptosis to promote tumorigenesis of colon cancer cells [50].