Dysfunctional maturation of DCs is characterized by the expression of lysosomal-associated membrane protein LAMP (DCLamp+), CD83 (DCCD83-) and MHC class II protein (DCMHCII,Low) Such DCs are located outside of tumor-associated tertiary lymphoid structures (NTLS-DC), particularly in the invasive margins of primary ccRCC tumors [168]. The gene discussed is LAMP3; the disease is neoplasm.