SH3 domain-binding glutamate rich protein-like 2 (SH3BGRL2) is involved in the suppression of EMT and metastasis in ccRCC tumors by inhibiting the nuclear translocation of YAP and its interaction with the TEAD coactivator in the nuclei [101]. Here, SH3BGRL2 is linked to nonpapillary renal cell carcinoma.