CD8A and renal cell carcinoma: Based on the histological analysis of RCC, the non-inflamed subtype is characterized by increased angiogenesis and plasmacytoid DCs and mast cell infiltrates, while the inflamed subtype showed high levels of complement system proteins and infiltrates of different immune cell types, such as Treg, NKs, Th, CD8+, B and activated DCs, as well as neutrophils, macrophages and eosinophils [30,31,32].