Forkhead activin signal transducer 1 (FAST1, FOXH1) is upregulated in RCC and mediates activation of the TGFβ/Smad signaling pathway, leading to increased cell viability, proliferation, migration, invasion, EMT, and reduced apoptosis as well as increased tumor growth [299]. The gene discussed is FOXH1; the disease is renal cell carcinoma.