FLT3LG and neoplasm: Therefore, many studies seek to specifically use natural endogenous DCs as vectors for DC vaccines (rather than artificial moDCs; given their potential for T-cell priming) in combination with adjuvants to stimulate them (Poly:ICLC, Flt3L), while attempting to abolish tumor-induced immunosuppression by combining these approaches with existing therapies such as ICBs or inhibitors of immunosuppressive cells.