AKT1S1 and Ewing sarcoma: In another investigation, it has been shown that PGK1 induced the phosphorylation of PRAS40 (the proline-rich AKT substrate of 40 kDa, encoded by the gene AKT1S1) at Thr246 in Ewing’s sarcoma cell line A673, and liver cancer cell lines HepG2 and SNU449.