PFKFB3 and colon adenocarcinoma: Klarer et al. demonstrated that the inhibition of PFKFB3 using either siRNA transfection or derivatives of the PFKFB3 inhibitor, 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), initiates survival autophagy in HCT-116 colon adenocarcinoma cells [123].