SQSTM1 and colorectal carcinoma: DHA can also induce autophagy in CRC cell lines, Caco-2 and SW620 (by regulating the expression of genes involved in the autophagy process, such as p62, LC3 and ATG14) [267], and the HCC cell line, HepG2 (shown by the accumulation of LC3-II and the formation of LC3puncta) [268].