BECN1 and neoplasm: Furthermore, the ROS/Akt/mTOR axis is activated by the inhibition of mitochondrial uncoupling protein 2 (UCP2) in pancreatic adenocarcinoma cells, which, in turn, leads to tumor cell growth arrest, induction of caspase-mediated apoptosis, and the translocation of GAPDH into the nucleus to promote BECLIN1-mediated autophagy [136].