The effects of three different Western diets, a low-fat diet, a high-fat diet, and a high-fat high-fructose diet exposure, on liver PPARγ/miRNA regulation were examined, and the results revealed that a high-fat, high-fructose diet induces an intermediate stage between fatty liver and fibrosis via miR-27b-5p-induced PPARγ downregulation [107]. This evidence concerns the gene PPARG and Hepatic steatosis.