Moreover, both diet-induced obese mice and NAFLD patients have considerably higher levels of the histone-lysine N-methyltransferase suppressor of variegation 3-9 homologue 2 (Suv39h2), which represses the expression of the Sirt1 and Pparγ genes [58]. This evidence concerns the gene SIRT1 and metabolic dysfunction-associated steatotic liver disease.