According to a study undertaken by Kim et al., the histone H3 lysine 4 (H3K4) methyltransferase myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4/KMT2D) regulates overnutrition-induced steatosis by acting as a coactivator for PPARγ2 through H3K4 methylation [56]. Here, KMT2D is linked to steatosis.