Along similar lines, analysis of a mouse model with an inducible Dkk1 expression cassette revealed that overexpression of Dkk1 in the adult brain reproduces several phenotypes in AD mouse models such as reduced synaptic transmission, impaired long-term potentiation, enhanced long-term depression, and long-term memory loss [223,224]. The gene discussed is DKK1; the disease is Alzheimer disease.