Consistently, our data showed low expression of TMPRSS2 in hLLCs, low efficacy of TMPRSS2 inhibitor blocking SARS-CoV-2 spike entry, and high expression of CTSB/CTSL in steroidogenic cells, suggesting that the endocrine system may be more vulnerable to SARS-CoV-2 omicron infections. Here, CTSB is linked to infection.