Moreover, we identified MLL-AF9-associated core genes that are faithfully represented in primary MLL-AF9 AML, including known targets such as HOXA10, CDK6, and ZNF521, as well as targets that have a presently unknown role in MLL-AF9 AML, e.g., SKIDA1, which seems to be a promising predictor of MLL-rearranged AML [45]. This evidence concerns the gene ZNF521 and acute myeloid leukemia.