FIS1 and amyotrophic lateral sclerosis: Importantly, suppressing mitochondrial fission with the small molecule DPR1 inhibitor Mdivi-1 [81], or with the P110 peptide that competitively inhibits the DRP1-Fis1 interaction [82], has reversed in vitro mitochondrial fragmentation provoked by ALS-linked mutations of SOD1, TDP43 or FUS1 [60,83].