SOD1 and amyotrophic lateral sclerosis: Moreover, CPR1 administered twice daily via the oral route to ALS SOD1 G93A mice from the time of initial phenotype onset (60 days) evoked a substantial delay in disease progression: the time courses over which RotaRod latency, inverted grip time, the combined neuromuscular function score and motor neuron electrical potential amplitude and conduction velocity deteriorated were delayed by 23–60%, depending upon individual metric.