Mechanistically, the in vivo benefits of mitofusin activation on SOD1 G93A ALS mice were recapitulated in vitro: CPR1 reduced ROS content and cell death in, and enhanced the regrowth of, cultured spinal motor neurons and dorsal root ganglion sensory neurons derived from the ALS mice. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.