In fpEC from GDM, it has been demonstrated that specific miRNAs lower ICAM-1 expression by post-translational effects compared to normal cells, which is suggested to be a protective placental endothelial cell-specific mechanism to avoid leukocyte transmigration and helps maintain a steady anti-inflammatory state regardless of the inflammatory milieu in conditions of GDM [64]. This evidence concerns the gene ICAM1 and gestational diabetes.