APOB and amyotrophic lateral sclerosis: In a 20-year follow-up study of a Swedish cohort of more than 600,000 individuals, Mariosa et al. [56] found that there is an increased risk of developing ALS with an elevated low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and LDL-C/high-density lipoprotein cholesterol (HDL-C) and apoB/apoA-I ratios.