Only one recent study linked TLSs to tumor angiogenesis by the assessment of HEVs and angiogenesis inside TLSs from colon cancer [62], and the authors briefly stated that less neovascularization around TLSs happens most probably due to the inhibitory effects of CD8+ T cells on endothelial cell proliferation and angiogenesis [63]. Here, CD8A is linked to malignant colon neoplasm.