APP and Alzheimer disease: For instance, in the cerebral area of cerebellum, superior parietal lobe, and inferior temporal lobe of AD patients, Iwata et al, by using pyrosequencing analysis, found statistically significant differences in DNA methylation levels at the promoter region of APP (Amyloid Beta Precursor Protein), MAPT (Microtubule Associated Protein Tau) and GSK3B (Glycogen Synthase Kinase 3 Beta) [187].