Considering that SLC1A5 is crucial for cellular glutamine homeostasis and given the pivotal role of glutamine for cardiac homeostasis, an inhibition of SLC1A5 expression in the myocardium may be responsible to reduce of glutamine uptake, with a consequence alteration of glutamine homeostasis that may contribute to myocardial energy derangements in the heart failure [161]. This evidence concerns the gene SLC1A5 and heart failure.