Based on the molecular structure of the protein, the OTUs superfamily can be divided into four subfamilies: the subfamily of proteins containing the ovarian tumor structural domain (OTUDs) (OTUD1, OTUD2/YOD1, OTUD3, OTUD4, OTUD5/DUBA, OTUD6A, OTUD6B and ALG13), the subfamily of ubiquitin aldehyde binding proteins (Otubains) containing the OTU structural domain (OTUB1 and OTUB2), the A20-like subfamily (A20, Cezanne2/OTUD7A, Cezanne/OTUD7B, TRABID/ZRANB1, VCPIP) and the OTU DUB with linear linkage specificity (OTULIN) [20,21]. This evidence concerns the gene ZRANB1 and ovarian neoplasm.