NPPB and left ventricular hypertrophy: A recent study that evaluated the effect of symbiotic administration on left ventricular hypertrophy and its effect on blood pressure and hsCRP as an inflammatory biomarker in chronic HF patients reported that, after 10 weeks of daily administration, the level of NT-proBNP, as a marker of left ventricular hypertrophy, decreased significantly in the symbiotic group compared to the placebo group.