A link between oxidative stress-induced degenerative processes of the kidney and ERK5 was provided by a study showing that treatment with eplerenone (a selective mineralocorticoid receptor antagonist) or tempol (a cell membrane-permeable radical scavenger, 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) prevented glomerular changes (i.e., cell proliferation and mesangial matrix expansion) and hypertension following the administration of aldosterone/1% NaCl to male Sprague-Dawley rats. Here, MAPK7 is linked to Hypertension.