Additional evidence of the protective role of ERK5 in HUVECs was provided by showing that two natural antioxidants, the stilbenes resveratrol and pterostilbene, activate MnSOD expression through the ERK5/HDAC5 pathway, thus alleviating mitochondrial oxidative stress in ECs that may be eventually associated with cardiovascular disease [96]. This evidence concerns the gene MAPK7 and cardiovascular disorder.