In these reported studies, the selective IKKβ inhibitor, BAY651942, suppressed mostly inflammation-related pathological phenomena, such as pulmonary inflammation in animal models of asthma, edema formation in the ear caused by chemical inducers [29], myocardial injury following acute ischemia-reperfusion injury [80], and lipopolysaccharide-induced neurotoxicity to dopamine neurons in a Parkinson’s disease model [30]. This evidence concerns the gene IKBKB and Parkinson disease.