Longer-duration Rupintrivir treatment also showed no significant alterations in mRNA expression profiles of antiviral IFNs (IFN-β1 and IFN-λ1), nor in the signature chemokine CXCL10, during secondary H3N2 infection or HRV-A16 re-infection as compared to infection of hNECs without treatment (Supplementary Figure S6E–G). This evidence concerns the gene IFNL1 and infection.