PFKFB3 and endometrial cancer: PFKFB3 has been suggested to play a role in promoting DNA damage repair (DDR), as an inhibitor of PFKFB3, PFK158, suppressed endometrial cancer cell proliferation, enhanced the sensitivity of the cells to carboplatin and cisplatin-induced DNA damage, and favored cell death, either apoptosis- or autophagy-mediated [126].