PFKFB3 and malignant pleural mesothelioma: Very recently, it has been shown that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) plays a crucial role in the maintenance of malignant pleural mesothelioma CSCs, and the PFKFB3 inhibitor PFK158 reduced CSC-mediated xenograft growth in vivo [112].