RUNX3 and gastric cancer: Aberrant upregulation of Runx3 has been observed in pancreatic cancer metastases, facilitated in KPC mice by loss of heterozygosity (LOH) of p53 [27,51], and in primary and metastatic gastric cancers, which develop in Pepsinogen C-CreER; KrasG12D/+Apcfl/flp53fl/fl mice [52].